EECP® : Simple, Safe, and Effective
Noninvasive treatment improves cardiac performance
by modifying hemodynamics

Adjustable cuffs are wrapped around      calves, lower thighs, and upper thighs,      including buttocks  Cuffs are activated by events in the      cardiac cycle via microprocessor      interpreted ECG signals   Cuffs inflate sequentially and rapidly      at the onset of diastole to prevent      blood from being trapped in vascular      beds  Cuffs deflate just prior to systole,      allowing a rapid drop in vascular      impediance and, consequently, cardiac      afterload

Diastolic perfusion pressure and the ratio      of the mean diastolic pressure to the      mean systolic pressure are increased   Coronary flow increases with diastolic      pressure since coronary vascular      resistance is minimal during cardiac      diastole   Coronary collateral flow to ischemic      regions of the myocardium is increased   Stroke volume per unit work, and      therefore efficiency of the left ventricle,      are increased   Left ventricular pressure and PTM      (pressure time per minute) are reduced,      or cardiac output is increased, or both      without increasing oxygen requirements

Visible evidence of hemodynamic effect on actual EECP® patient 10  Systolic unloading reduces energy requirements of the heart  Dramatic diastolic augmentation (equal to or greater than intraaortic balloon pump)

Doppler echo of the descending aorta during EECP® treatment 10  Increased retrograde diastolic and      enhanced systolic flow

A simple regimen provides symptomatic relief  In clinical trials, EECP® provided      symptomatic improvement after a course      of 35 one-hour sessions  Recommended regimen is once-daily 1      hour treatment, 5 days a week for 7      weeks  Twice-daily treatment is an option in      some patients, to reduce treatment      course duration  Extending treatment beyond 35 sessions      may benefit some patients

Clinical trials demonstrate EECP® safety 2,4,5  Noninvasive, outpatient treatment does not      require hospitalization  No major adverse events were reported      with EECP® therapy - leg discomfort, the     most common adverse event reported,      rarely leads to discontinuation